Oncogenes and anti-oncogenes in tumorigenesis

Related Experiment Video

Updated: Nov 3, 2026

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

R Monier1

  • 1Institut Gustave-Roussy, UA CNRS 1158, Laboratoire d'Oncologie moléculaire, Villejuif, France.

Reproduction, Nutrition, Development
|January 1, 1990
PubMed

Insights

Cellular genes, including proto-oncogenes and tumor suppressor genes, drive cancer initiation and progression. Genetic alterations in these genes accumulate, leading to the development of invasive tumors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cellular genes play critical roles in regulating cell proliferation and differentiation.
  • Alterations in these genes are implicated in the development of cancer.
  • Proto-oncogenes and tumor suppressor genes are key players in tumorigenesis.

Purpose of the Study:

  • To elucidate the roles of proto-oncogenes and tumor suppressor genes in cancer development.
  • To understand the genetic mechanisms underlying tumor initiation and progression.
  • To explain the cooperative effect of genetic events in malignant transformation.

Main Methods:

  • Identification of cellular genes involved in tumorigenesis.
  • Analysis of genetic alterations in proto-oncogenes and tumor suppressor genes.
  • Study of gene expression regulation and coding sequence modifications.

Main Results:

  • Proto-oncogenes, when altered, contribute dominantly to the tumorigenic phenotype.
  • Loss of function in tumor suppressor genes (recessive oncogenes) contributes recessively to tumorigenesis.
  • Accumulation of genetic events affecting both gene types drives tumor progression.

Conclusions:

  • Both proto-oncogenes and tumor suppressor genes are essential in cancer initiation and progression.
  • Cooperative genetic events involving these genes lead to the malignant invasive phenotype of advanced tumors.
  • Understanding these genetic mechanisms is crucial for cancer research and therapeutic development.

More Related Videos

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...