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Updated: Jun 3, 2026

Non-Invasive Compression-Induced Anterior Cruciate Ligament (ACL) Injury and In Vivo Imaging of Protease Activity in Mice
Published on: September 29, 2023
Contact sport and osteoarthritis
Michael G Molloy1, Catherine B Molloy
1Department of Rheumatology and Medicine, Cork University Hospital, Cork, Ireland. mgmmolloy@eircom.net
Moderate exercise and sports participation generally protect against osteoarthritis (OA). However, contact sports and anterior cruciate ligament (ACL) injuries increase the risk of developing OA, especially in the knee and hip.
Area of Science:
- Orthopedics
- Sports Medicine
- Rheumatology
Background:
- Osteoarthritis (OA) is a prevalent degenerative joint disease and a leading cause of disability.
- OA incidence and prevalence increase with age, affecting over twice as many people as cardiac disease.
Purpose of the Study:
- To evaluate the relationship between exercise, sports participation, and the risk of developing osteoarthritis.
- To examine the impact of specific sports and injuries on hip and knee OA development.
Main Methods:
- Review of animal and human studies on exercise and OA risk.
- Analysis of case-control studies on recreational runners and OA.
- Examination of OA rates in contact sports athletes compared to controls.
- Investigation of knee OA risk in soccer players with and without anterior cruciate ligament (ACL) injuries.
Main Results:
- Moderate exercise and non-traumatic sporting activities show a protective effect against hip and knee OA.
- Recreational runners logging 12-14 miles weekly for decades showed no increased OA risk.
- Contact sports are associated with higher hip OA rates, particularly in professional athletes.
- ACL injuries significantly increase the likelihood of developing knee OA, even after early repair.
Conclusions:
- While generally beneficial, certain high-impact or contact sports carry an elevated risk for OA.
- Preventing injuries like ACL ruptures through established programs is crucial for mitigating OA risk in athletes.
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