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Related Concept Videos

Diabetic Ketoacidosis l: Introduction01:25

Diabetic Ketoacidosis l: Introduction

DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic ketone production, and...
Diabetic Ketoacidosis ll: Pathophysiology01:22

Diabetic Ketoacidosis ll: Pathophysiology

Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...

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Related Experiment Video

Updated: Jun 3, 2026

Site-Specific Lysine Lactylation via Genetic Code Expansion in E. coli and Mammalian Cells
05:58

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Published on: February 24, 2026

Type B lactic acidosis in solid malignancies.

R de Groot1, R A Sprenger, A L T Imholz

  • 1Department of Internal Medicine, Deventer Hospital, Deventer, The Netherlands. R.Grootde@dz.nl

The Netherlands Journal of Medicine
|March 30, 2011
PubMed
Summary
This summary is machine-generated.

Type B lactic acidosis, a rare cancer complication, can occur in solid tumors. This oncological emergency may stem from tumor cell overproduction of lactic acid due to ischemia and aberrant energy metabolism.

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Area of Science:

  • Oncology
  • Medical Biochemistry

Background:

  • Type B lactic acidosis is a rare complication associated with malignancy.
  • Initially described in acute leukemia, it is more frequently observed in hematological malignancies but rarely in solid tumors.

Observation:

  • This study reviews previously reported cases of lactic acidosis in solid malignancy.
  • A case of type B lactic acidosis in a patient with metastatic breast cancer is presented.
  • 14 cases of lactic acidosis attributed to solid malignancies, without prior chemotherapy, were identified from 1978 to 2006.

Findings:

  • The pathophysiology of type B lactic acidosis in solid tumors remains elusive.
  • Current theories suggest a role for lactic acid overproduction by neoplastic tissue.
  • Aberrant energy production within cancer cells is also implicated.

Implications:

  • Understanding the mechanisms of type B lactic acidosis in solid tumors is crucial for managing this oncological emergency.
  • Further research into tumor cell metabolism and ischemia is warranted.
  • This condition highlights the complex metabolic interactions between cancer and the host organism.