Next-generation association studies for complex traits
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Updated: Jun 3, 2026

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Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. eleftheria@sanger.ac.uk
Nature Genetics
|March 30, 2011
Abstract:
A new study successfully applies complementary whole-genome sequencing and imputation approaches to establish robust disease associations in an isolated population. This strategy is poised to help elucidate the role of variants at the low end of the allele frequency spectrum in the genetic architecture of complex traits.
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