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Related Experiment Videos

Developing forebrain astrocytes are sensitive to thyroid hormone.

E Gould1, M Frankfurt, A Westlind-Danielsson

  • 1Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021.

Glia
|January 1, 1990
PubMed
Summary

Thyroid hormone accelerates astrocyte development in the brain, impacting glial fibrillary acidic protein (GFAP) and vimentin expression in developing neurons. This study reveals thyroid hormone

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Endocrinology

Background:

  • Developing neurons in the basal forebrain and hippocampus are known to be sensitive to thyroid hormone.
  • The influence of thyroid hormone on astrocyte development in these sensitive brain regions remains less understood.

Purpose of the Study:

  • To investigate the effect of neonatal thyroid hormone administration on astrocyte development in the basal forebrain and hippocampus.
  • To compare these effects with glial cell development in a thyroid hormone-insensitive region (pontomesencephalotegmental region).

Main Methods:

  • Vimentin and glial fibrillary acidic protein (GFAP) immunocytochemistry.
  • Single-section Golgi-impregnation analysis.
  • Comparative study in control and neonatally thyroid hormone-treated rats.

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Main Results:

  • Neonatal thyroid hormone treatment led to premature disappearance of vimentin-immunoreactive radial glia.
  • A premature appearance of mature GFAP-immunoreactive astrocytes was observed.
  • Increased astrocyte density, cell body area, and primary process number in treated basal forebrain and hippocampus.

Conclusions:

  • Thyroid hormone accelerates astrocyte maturation and development in the basal forebrain and hippocampus.
  • Glial cells in the pontomesencephalotegmental region were unaffected by neonatal thyroid hormone treatment.
  • Thyroid hormone plays a critical role in the timing of astrocyte development in specific brain regions.