Related Experiment Video
Updated: Jun 3, 2026
08:03
Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
Published on: June 11, 2017
Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner
Hayden-William Courtland1, Sebastien Elis, Yingjie Wu
1Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, New York, United States of America.
Plos One
|March 30, 2011
Summary
Serum Insulin-like Growth Factor-1 (IGF-1) is crucial for bone accrual during growth. Depleting IGF-1 after peak bone mass enhances trabecular bone but does not harm cortical bone in adult mice.
Area of Science:
- Endocrinology
- Bone Biology
- Skeletal Physiology
Background:
- Insulin-like Growth Factor-1 (IGF-1) is vital for skeletal development and bone mass maintenance.
- Decreased serum IGF-1 levels correlate with reduced bone mineral density (BMD) in aging.
- Previous mouse models could not isolate the timing of IGF-1's skeletal effects.
Purpose of the Study:
- To investigate the temporal effects of IGF-1 depletion on skeletal compartments.
- To characterize the skeletal changes in inducible IGF-1 deficient (iLID) mice at different ages.
- To determine if IGF-1 is essential for maintaining bone mass after peak acquisition.
Main Methods:
- Skeletal characterization of inducible LID (iLID) mice with IGF-1 depletion at selected ages.
- Analysis of trabecular and cortical bone properties at various time points.
- Comparison of bone parameters between iLID mice and control groups.
Main Results:
- IGF-1 depletion before adulthood (4 weeks) impaired trabecular and cortical bone in male mice.
- IGF-1 depletion at 8 weeks reduced cortical bone properties but not trabecular bone in late adulthood.
- IGF-1 depletion after peak bone acquisition (16 weeks) improved trabecular bone without affecting cortical bone.
Conclusions:
- Serum IGF-1 is essential for bone accrual during postnatal growth.
- Post-peak bone acquisition, IGF-1 depletion has compartment-specific effects.
- IGF-1 is not detrimental to cortical bone mass in older adult mice after peak acquisition.
Related Concept Videos
01:17Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:27Signs of Puberty
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
02:30Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
01:10Nature and Nurture
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
01:16TGF - β Signaling Pathway
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...