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Selective constraints on amino acids estimated by a mechanistic codon substitution model with multiple nucleotide

Sanzo Miyazawa1

  • 1Graduate School of Engineering, Gunma University, Kiryu, Gunma, Japan. miyazawa@smlab.sci.gunma-u.ac.jp

Plos One
|March 30, 2011
PubMed
Summary

A new codon-based model tailors substitution tendencies and selective constraints to individual genes, improving molecular phylogenetic tree inferences. This approach offers biologically meaningful insights at both nucleotide and amino acid levels.

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