Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
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Published on: December 19, 2019
Roberta Alves Higa1, Ricardo Dutra Aydos, Iandara Schettert Silva
1Health and Development Postgraduate Program, UFMS, Campo Grande-MS, Brazil.
Purpose:
To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice.
Methods:
Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II - β-lapachone, in group III - vehicle (diluent) and in group IV - vehicle + AOM and finally in group V - β-lapachone + AOM.
Results:
It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V.
Conclusion:
The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice.
Insights
Beta-lapachone from Tabebuia avellanedae did not protect against colon cancer induced by azoxymethane (AOM) in mice. Aberrant crypt foci were observed in most treated groups, indicating no protective effect.
Area of Science:
- Pharmacology
- Oncology
- Natural Products
Background:
- Colon cancer is a significant health concern.
- Azoxymethane (AOM) is a chemical inducer used in experimental colon carcinogenesis models.
- Tabebuia avellanedae is a plant with traditional medicinal uses.
Purpose of the Study:
- To investigate the potential antitumor effects of beta-lapachone, a compound from Tabebuia avellanedae.
- To evaluate the efficacy of beta-lapachone in preventing colon carcinogenesis induced by azoxymethane in a mouse model.
Main Methods:
- Fifty mice were divided into five experimental groups.
- Groups received azoxymethane (AOM), beta-lapachone, vehicle, or combinations thereof.
- Aberrant crypt foci (ACF) were assessed as a biomarker for colon carcinogenesis.
Main Results:
- Aberrant crypt foci were present in all animals in the azoxymethane (Group I) and vehicle + AOM (Group IV) groups.
- Fifty percent of animals in the beta-lapachone only group (Group II) showed ACF.
- Ninety percent of animals in the beta-lapachone + AOM group (Group V) exhibited ACF.
Conclusions:
- Beta-lapachone extracted from Tabebuia avellanedae demonstrated no protective effect against azoxymethane-induced colon lesions in mice.
- The compound did not inhibit the formation of aberrant crypt foci in this experimental model.
- Further research may be needed to explore other potential therapeutic applications or mechanisms of beta-lapachone.
