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Updated: Jun 3, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
Published on: August 9, 2013
[Uncaria tomentosa and acute ischemic kidney injury in rats]
Maria de Fátima Fernandes Vattimo1, Natalia Oliveira da Silva
1Universidade de São Paulo, São Paulo, SP, Brazil. nephron@usp.br
Abstract:
The objective of this study was to evaluate the renoprotective effects of Uncaria Tomentosa (cat's claw) on ischemic acute kidney injury induced by renal clamping in rats. The hypoxia and hypoperfusion increase the production of reactive species already present in the inflammatory process. Results showed that the renal function evaluated by creatinine clearance, the urinary excretion of peroxides and malondealdehyde indexes demonstrated that UT induced renoprotection, probably related to its antioxidant activities.
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