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Updated: Jun 3, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Surgery for peritoneal mesothelioma.

Keli M Turner¹, Sheelu Varghese, H Richard Alexander

¹Department of Surgery, University of Maryland Medical Center, 22 S. Greene St., Baltimore, MD 21201, USA. kturner@smail.umaryland.edu

Current Treatment Options in Oncology

|March 30, 2011

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Malignant peritoneal mesothelioma (MPM) treatment with cytoreduction and hyperthermic intra-operative perfusion of intraperitoneal chemotherapy (HIPEC) offers improved survival. This approach is recommended as the standard of care for eligible MPM patients.

Area of Science:

Oncology
Surgical Oncology

Background:

Malignant peritoneal mesothelioma (MPM) is a rare, aggressive cancer.
MPM arises from the abdominal cavity's serosa and is typically fatal.

Purpose of the Study:

To evaluate the efficacy of cytoreduction and hyperthermic intra-operative perfusion of intraperitoneal chemotherapy (HIPEC) for MPM.
To establish cytoreduction and HIPEC as the standard of care for MPM.

Main Methods:

Surgical cytoreduction combined with HIPEC.
Multimodal approaches including EPIC chemotherapy and radiotherapy were also considered.

Main Results:

Median overall survival up to 7 years observed with cytoreduction and HIPEC.
Complete palliation of ascites achieved in most cases.

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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

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Favorable prognostic factors include female gender, age ≤ 60, and complete disease removal.

Conclusions:

Cytoreduction and HIPEC demonstrate the best survival outcomes for MPM.
This surgical approach is recommended as the standard of care for MPM when feasible and safe.