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Updated: Jun 3, 2026

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
Published on: August 1, 2022
Postnatal in-vivo MRI findings in anencephaly
A Poretti1, A Meoded, E Ceritoglu
1Division of Pediatric Radiology, The Johns Hopkins School of Medicine Baltimore, Maryland 21287, USA.
Abstract:
We report on the MRI findings of an anencephalic infant who survived 10 weeks postnatally. MRI showed absence of the cranial vault, all supratentorial structures, and the cerebellum. A brainstem primordium without pontine prominence was present. The brainstem was surrounded by the area cerebrovasculosa. The absence of a pontine prominence in an anencephalic infant without cerebellar tissue supports the hypothesis that absent pontine prominence is found in children with a prenatal loss of cerebellar tissue.
