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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Cutaneous hematologic disorders in children.

Olivia Boccara1, Stéphane Blanche, Yves de Prost

  • 1Department of Pathology, Hôpital Necker-Enfants Malades, AP-HP, Université René Descartes, Paris V, France.

Pediatric Blood & Cancer
|March 30, 2011
PubMed
Summary
This summary is machine-generated.

Childhood cutaneous hematologic diseases, primarily lymphomatoid papulosis (LyP), differ from adult presentations. Pityriasis lichenoides chronica (PLC) often precedes LyP and mycosis fungoides (MF).

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Area of Science:

  • Pediatric Hematology
  • Dermatology
  • Oncology

Background:

  • Cutaneous hematologic diseases in children present unique clinical and pathological features.
  • Understanding these features is crucial for accurate diagnosis and management in pediatric patients.

Purpose of the Study:

  • To determine and list the clinical and pathological features of cutaneous hematologic diseases in children under 15 years old.
  • To compare childhood presentations with those typically seen in adults.

Main Methods:

  • Retrospective analysis of 51 pediatric patients (age ≤15) with primary cutaneous hematologic disorders.
  • Classification based on WHO-EORTC criteria, including lymphomatoid papulosis (LyP), lymphoblastic lymphoma (LL), acute leukemias (AL), mycosis fungoides (MF), and EBV-related lymphoproliferative disorders (EBV-related LPD).

Main Results:

  • Lymphomatoid papulosis (LyP) was the most common diagnosis.
  • Pityriasis lichenoides chronica (PLC) preceded disease onset in 29% of LyP and 80% of MF cases.
  • Acute leukemias (AL) and lymphoblastic lymphoma (LL) showed stereotypical features aiding prompt diagnosis, while mycosis fungoides (MF) was often initially underdiagnosed.

Conclusions:

  • Cutaneous hematologic disease distribution differs between pediatric and adult populations.
  • Pityriasis lichenoides chronica (PLC) is strongly associated with mycosis fungoides (MF) and LyP.
  • Awareness of stereotypical presentations of LL and AL is vital for timely pediatric diagnosis and treatment.