Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the subthalamic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebral Energy Crisis in the Subacute Phase of Aneurysmal Subarachnoid Hemorrhage: A 31P-MRS Pilot Study on Cerebral Vasospasm and Delayed Cerebral Ischemia.

Neurocritical care·2026
Same author

Efficacy of digital therapeutic sinCephalea for personalised nutrition versus control for migraine prevention: A 12-week open-label randomised clinical trial.

Cephalalgia : an international journal of headache·2026
Same author

HERMES-24 score for outcome prediction in large vessel occlusion stroke: Real-world data from the Austrian stroke network.

International journal of stroke : official journal of the International Stroke Society·2026
Same author

Can rimegepant stop symptoms of a migraine attack in people who have not found triptans to work well or are not recommended to use triptans? A plain language summary of a clinical study.

Pain management·2026
Same author

Prevalence and predictors of persistent post-COVID pain: a population-based prospective cohort study with 1.5-year follow-up.

Pain·2026
Same author

Letter to the Editor: Reaffirming Caution-The Unacceptable Vasoconstrictive Risk of CGRP-Related Therapies in Moyamoya Angiopathy.

European journal of neurology·2026

Related Experiment Video

Updated: Jun 3, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Hypothalamic gray matter volume loss in hypnic headache.

Dagny Holle1, Steffen Naegel, Sarah Krebs

  • 1Department of Neurology, University of Duisburg-Essen, Germany. dagny.holle@uk-essen.de

Annals of Neurology
|March 30, 2011
PubMed
Summary

Hypnic headache (HH) is a rare nocturnal headache. Research shows reduced gray matter in the posterior hypothalamus of HH patients, suggesting its role in sleep and pain regulation.

More Related Videos

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
02:22

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Jun 3, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
02:22

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Area of Science:

  • Neurology
  • Neuroimaging
  • Sleep Medicine

Background:

  • Hypnic headache (HH) is a rare primary headache disorder.
  • Characterized by strictly nocturnal headache attacks occurring at consistent times.
  • Pathophysiology is poorly understood, with suspected hypothalamic involvement due to its role in sleep and pain control.

Purpose of the Study:

  • To investigate the role of the hypothalamus in the pathophysiology of hypnic headache.
  • To identify structural brain differences in patients with hypnic headache compared to healthy controls.

Main Methods:

  • Voxel-based morphometry (VBM) using magnetic resonance imaging (MRI).
  • Comparison of 14 patients with HH against 14 age- and gender-matched healthy controls.

Main Results:

  • Significant gray matter volume decrease in the posterior hypothalamus of HH patients.
  • Additional gray matter reductions observed in brain regions associated with pain processing (cingulate cortex, operculum, frontal lobe) and the temporal lobe.

Conclusions:

  • The findings support the hypothesis of posterior hypothalamic involvement in HH pathophysiology.
  • The hypothalamus plays a crucial role in regulating both sleep and pain perception in hypnic headache.