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Updated: Jun 3, 2026

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
Published on: June 21, 2024
Two-dimensional phase cycled reconstruction for inherent correction of echo-planar imaging Nyquist artifacts
Nan-Kuei Chen1, Alexandru V Avram, Allen W Song
1Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina 27705, USA. nankuei.chen@duke.edu
This study introduces a novel 2D phase correction technique for echo-planar imaging (EPI) to eliminate Nyquist artifacts. The method effectively removes artifacts without needing extra scans or risking motion-related errors, improving image quality.
Area of Science:
- Medical Imaging
- Magnetic Resonance Imaging
- Image Reconstruction
Background:
- Echo-planar imaging (EPI) is prone to Nyquist artifacts due to inconsistent k-space trajectories.
- Existing one-dimensional correction methods are insufficient, especially for oblique EPI or with eddy currents.
- Current two-dimensional (2D) correction methods often require reference scans and are sensitive to motion-induced errors.
Purpose of the Study:
- To develop an inherent and general 2D phase correction technique for EPI Nyquist artifact removal.
- To overcome limitations of existing methods, including the need for reference scans and susceptibility to motion artifacts.
- To enhance the quality of EPI images across various imaging protocols.
Main Methods:
- A 2D reconstruction framework generates a series of images by iterating through potential phase error values.
- Artifact level is assessed using background energy criteria in sorted and sigmoid-weighted signals.
- The optimal image with minimal artifacts is selected from the generated series.
Main Results:
- The proposed method effectively removes Nyquist ghosts in single-shot, segmented, and parallel EPI.
- No additional reference scans are required, simplifying the imaging protocol.
- The technique avoids error amplification associated with subject motion during reconstruction.
Conclusions:
- This inherent 2D phase correction is a general and effective solution for EPI Nyquist artifact removal.
- The method improves image quality without compromising scan time or introducing motion sensitivity.
- It offers a robust alternative to traditional and existing 2D correction techniques.
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