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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Updated: Jun 3, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

The brain tumor microenvironment.

Nikki A Charles1, Eric C Holland, Richard Gilbertson

  • 1Departments of Surgery (Neurosurgery), Neurology, and Cancer Biology & Genetics, Memorial Sloan-Kettering Cancer Center, New York, USA. charlen2@mskcc.org

Glia
|March 30, 2011
PubMed
Summary
This summary is machine-generated.

High-grade brain tumors involve complex interactions between tumor cells and surrounding brain cells. Understanding these cell-cell communications is key to developing new glioblastoma treatments.

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Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

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Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
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Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
10:13

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

Area of Science:

  • Neuro-oncology
  • Cell Biology
  • Tumor Microenvironment

Background:

  • High-grade brain tumors, like glioblastomas, are heterogeneous, containing various cell types including stem-like cells.
  • Tumor-associated parenchymal cells (vascular, immune, neural precursors) significantly influence tumor progression.
  • Stem-like cells are implicated as the origin of tumor recurrence.

Purpose of the Study:

  • To review interactions between glioma cells (bulk and stem) and parenchymal cells.
  • To highlight the pathological impact and signaling pathways involved in this cell-cell communication.
  • To provide a new perspective on primary brain tumor cell biology for potential therapeutic development.

Main Methods:

  • Literature review of existing studies on glioma cell interactions.
  • Analysis of signaling pathways and pathological impacts of cell-cell communication.
  • Synthesis of current knowledge on the tumor microenvironment in high-grade brain tumors.

Main Results:

  • Tumor vasculature supports glioblastomas and harbors stem-like cells.
  • Microglia contribute to glioblastoma invasion.
  • Reactive astrocytes and endogenous neural stem/progenitor cells influence tumor biology through secreted factors.

Conclusions:

  • Interactions between tumor and parenchymal cells are critical for understanding brain tumor progression.
  • Identifying these pathways offers potential for novel therapeutic strategies.
  • Further research is needed to fully elucidate the complex cell-cell interactions in gliomas.