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Related Concept Videos

Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
Body Temperature01:07

Body Temperature

Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...
Body Temperature01:25

Body Temperature

The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...

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Related Experiment Video

Updated: Jun 3, 2026

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
04:54

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Published on: June 2, 2023

Temperatures rising: brown fat and bone.

Katherine J Motyl1, Clifford J Rosen

  • 1Center for Clinical and Translational Research, Maine Medical Center Research Institute, 81 Research Drive, Portland, Maine 04074, USA.

Discovery Medicine
|March 31, 2011
PubMed
Summary

Caloric restriction impacts bone density, potentially through brown adipose tissue (BAT) dysfunction. This study explores the link between BAT, thermoregulation, and age-related bone loss.

Area of Science:

  • Bone Biology
  • Metabolic Regulation
  • Adipose Tissue Biology

Background:

  • Caloric restriction reduces body weight and temperature, affecting bone marrow adipocytes and trabecular bone volume.
  • Brown adipocytes may directly influence bone remodeling, as seen in heterotrophic ossification and osteosarcoma models.
  • Aging leads to brown adipose tissue (BAT) senescence, altered thermoregulation, bone loss, and increased sympathetic activity, suggesting a potential role for BAT in senile osteoporosis.

Purpose of the Study:

  • To review the current evidence linking brown adipose tissue (BAT) and bone health.
  • To provide novel insights into how thermoregulation impacts bone mineral density.
  • To explore the potential indirect role of BAT dysfunction in age-related bone loss.

Main Methods:

More Related Videos

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
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Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Related Experiment Videos

Last Updated: Jun 3, 2026

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
04:54

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Published on: June 2, 2023

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

  • Literature review of studies on caloric restriction, brown adipose tissue, bone remodeling, and thermoregulation.
  • Analysis of emerging evidence on the direct and indirect effects of brown adipocytes on bone.
  • Synthesis of data connecting aging, sympathetic activity, heart rate, and fracture risk.

    • Main Results:

    • Brown adipocytes are implicated in bone formation processes and may be linked to osteosarcoma development.
    • Sympathetic nervous system activity, indicated by heart rate, is a predictor of fracture risk in the elderly.
    • Evidence suggests a possible indirect role of thermogenic dysfunction, potentially involving BAT, in age-related bone loss, though direct evidence is limited.

    Conclusions:

    • Brown adipose tissue (BAT) and thermoregulation are increasingly recognized as factors influencing bone health.
    • Further research is needed to elucidate the mechanisms by which BAT dysfunction contributes to age-related bone loss and affects bone mineral density.
    • Understanding the interplay between BAT, thermogenesis, and bone metabolism may reveal new therapeutic targets for osteoporosis.