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Updated: Jun 3, 2026

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry
Published on: September 15, 2020
Synchrotron radiation infrared microspectroscopy to assess the activity of vancomycin against endocarditis vegetation
Eric Batard1, Frédéric Jamme, Emmanuel Montassier
1Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, Nantes, France. eric.batard@chu-nantes.fr
Abstract:
Infrared microspectroscopy was used to show that vancomycin alters infrared spectra of endocarditis vegetation bacteria, and that vancomycin effects on bacterial biochemical contents are unevenly distributed between peripheral and central areas of bacterial masses. Infrared microspectroscopy is useful to study the activity of antibacterial agents against bacteria in tissues.
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