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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Cyclosporin A--a review on fermentative production, downstream processing and pharmacological applications
Shrikant A Survase1, Lalit D Kagliwal, Uday S Annapure
1Food Engineering and Technology Department, Institute of Chemical Technology, Matunga, Mumbai 400019, India.
Abstract:
In present times, the immunosuppressants have gained considerable importance in the world market. Cyclosporin A (CyA) is a cyclic undecapeptide with a variety of biological activities including immunosuppressive, anti-inflammatory, antifungal and antiparasitic properties. CyA is produced by various types of fermentation techniques using Tolypocladium inflatum. In the present review, we discuss the biosynthetic pathway, fermentative production, downstream processing and pharmacological activities of CyA.
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