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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
UniProt Knowledgebase: a hub of integrated protein data
1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. magrane@ebi.ac.uk
Database : the Journal of Biological Databases and Curation
|March 31, 2011
Summary
The UniProt Knowledgebase (UniProtKB) is a central protein information hub. It integrates diverse data, ensuring traceability and promoting data sharing for broader research access.
Area of Science:
- Bioinformatics
- Proteomics
- Molecular Biology
Background:
- The UniProt Knowledgebase (UniProtKB) serves as a critical resource for protein sequence and functional data.
- Effective protein data management requires integration and cross-referencing with numerous external databases.
- Ensuring data provenance and accessibility is essential for scientific reproducibility and discovery.
Purpose of the Study:
- To describe the structure and content of the UniProt Knowledgebase (UniProtKB).
- To highlight the methods used for data annotation and integration within UniProtKB.
- To emphasize the importance of data accessibility and standardized formats for the scientific community.
Main Methods:
- Manual and automated annotation processes for data entry into UniProtKB.
- Extensive cross-referencing to over 120 specialized external databases.
- Integration of data from diverse biological resources.
Main Results:
- UniProtKB provides a unified view of protein sequence and function.
- Data provenance is maintained through clear attribution to original sources.
- UniProtKB facilitates access to specialized information via cross-references.
Conclusions:
- UniProtKB is a comprehensive and reliable central hub for protein knowledge.
- The commitment to data sharing and common formats enhances its utility for researchers.
- UniProtKB supports the integration of protein information across different biological databases.
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