Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rolling Resistance: Problem Solving01:17

Rolling Resistance: Problem Solving

Rolling resistance, also known as rolling friction, is the force that resists the motion of a rolling object, such as a wheel, tire, or ball, when it moves over a surface. It is caused by the deformation of the object and the surface in contact with each other, as well as other factors like internal friction, hysteresis, and energy losses within the materials. Rolling resistance opposes the object's motion, requiring additional energy to overcome it and maintain movement. In practical...
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
Bending of Material: Problem Solving01:09

Bending of Material: Problem Solving

In this lesson, determine the ratio of the maximum bending moments applied to two metal pipes, given that both pipes can withstand a maximum stress of 100 MPa. Both pipes have an outer radius of 1.8 cm. Pipe A has an inner radius of 1.5 cm, and Pipe B has an inner radius of 1 cm. The ratio of the maximum bending moment applied to two metallic pipes, each with a different inner and outer radius, is determined by considering their dimensions. The inner radius of the first pipe is 1.5 cm, and for...
Friction: Problem Solving01:21

Friction: Problem Solving

Friction is an essential force that influences the motion of objects in daily life. Depending on the situation, it can be either beneficial or problematic. Consider a bus with a mass of three megagrams and its center of mass at a specific point, moving along a banked road at a constant speed. The coefficient of static friction between the tires and the road is 0.5. Find the maximum angle of the banked road at which the bus would not slip or tip.
Initially, a visual representation of the...
Prismatic Beams: Problem Solving01:15

Prismatic Beams: Problem Solving

In the design of a supported timber beam subjected to a distributed load, both the beam's physical dimensions and the timber's characteristics, such as its grade and species, are critical. These factors determine the allowable stress values, which are crucial for calculating the necessary beam depth to ensure structural integrity and safety.
The design begins with analyzing the beam as a free body to identify moments and force balances, thereby determining support reactions. Next, the designer...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conformational landscape adaptations enable processive phosphorylation by Src family kinases.

Science (New York, N.Y.)·2025
Same author

Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors.

Science signaling·2025
Same author

Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.

bioRxiv : the preprint server for biology·2024
Same author

Exploring the conformational landscape of protein kinases.

Current opinion in structural biology·2024
Same author

Mechanisms and clinical significance of TGF-β in hepatocellular cancer progression.

Advances in cancer research·2022
Same author

Using quantitative immunohistochemistry in patients at high risk for hepatocellular cancer.

Genes & cancer·2022
Same journal

ZNRF3 and RNF43 are active monomeric E3 ubiquitin ligases that self-associate.

Science signaling·2026
Same journal

Allosteric ligands with distinct properties uncover tissue-specific physiological regulation mediated by free fatty acid receptor 2.

Science signaling·2026
Same journal

Diacylglycerol kinase ζ in B lymphocytes supports CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell fate.

Science signaling·2026
Same journal

The APC/C adaptor Cdh1 stabilizes STING to potentiate innate immune activation in renal cell carcinoma.

Science signaling·2026
Same journal

Fattening mother's milk with oxytocin.

Science signaling·2026
Same journal

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B.

Science signaling·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

EasyFiji: A Graphical Interface for User-Friendly Fluorescence Image Processing in Fiji
10:09

EasyFiji: A Graphical Interface for User-Friendly Fluorescence Image Processing in Fiji

Published on: February 20, 2026

Focus issue: Rendering resistance futile.

Elizabeth M Adler, Nancy R Gough

    Science Signaling
    |March 31, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Cancer cells can develop resistance to chemotherapy and targeted therapies. This issue explores the underlying molecular mechanisms of this drug resistance.

    More Related Videos

    Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
    12:12

    Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

    Published on: May 14, 2014

    Related Experiment Videos

    Last Updated: Jun 3, 2026

    EasyFiji: A Graphical Interface for User-Friendly Fluorescence Image Processing in Fiji
    10:09

    EasyFiji: A Graphical Interface for User-Friendly Fluorescence Image Processing in Fiji

    Published on: February 20, 2026

    Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
    12:12

    Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

    Published on: May 14, 2014

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Research

    Background:

    • This issue complements the Science special issue on cancer.
    • Focuses on mechanisms of antineoplastic therapy resistance in cancer cells.

    Discussion:

    • Explores resistance to classical chemotherapy drugs targeting rapidly proliferating cells.
    • Investigates resistance to newer agents inhibiting oncogenic kinases or signaling pathways.

    Key Insights:

    • Cancer cells develop resistance through diverse molecular mechanisms.
    • Understanding these mechanisms is crucial for overcoming treatment failure.

    Outlook:

    • Highlights the need for further research into drug resistance pathways.
    • Aims to inform the development of more effective cancer treatments.