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Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence

Cornelia Hömig-Hölzel1, Remco van Doorn, Celia Vogel

  • 1Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

The EMBO Journal
|March 31, 2011
PubMed
Summary

Oncogene-induced cellular senescence (OIS) suppresses tumors by regulating TGFβ-stimulated clone 22 (TSC22D1) variants. Differential regulation of these TSC22D1 forms is crucial for establishing OIS and controlling BRAF(E600) driven cancers.

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