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The bone marrow stroma in hematological neoplasms--a guilty bystander
Claudio Tripodo1, Sabina Sangaletti, Pier P Piccaluga
1Department of Human Pathology, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy. tripodo@unipa.it
Nature Reviews. Clinical Oncology
|March 31, 2011
Summary
Bone marrow stroma changes are crucial in hematological neoplasms, influencing disease progression and prognosis. Targeting these stromal modifications offers a promising therapeutic strategy for blood cancers.
Area of Science:
- Hematology
- Oncology
- Cell Biology
Background:
- Bone marrow (BM) stroma undergoes significant changes in hematological neoplasms due to neoplastic clone pressure and BM homeostasis perturbation.
- Alterations in BM stromal composition can be profound and serve as critical prognostic factors in these malignancies.
Purpose of the Study:
- To review the multifaceted role of BM stroma in the pathobiology of hematological neoplasms.
- To discuss how stromal modifications impact disease progression and explore mechanisms of BM stroma remodeling.
- To highlight the potential of targeting BM stroma in therapeutic strategies.
Main Methods:
- Literature review of studies on bone marrow stroma in hematological neoplasms.
- Analysis of the pathobiology and prognostic significance of stromal changes.
- Synthesis of current knowledge on BM stroma remodeling processes.
Main Results:
- BM stromal components are involved in both lymphoid and myeloid malignancies.
- Specific remodeling processes of the BM stroma have been identified.
- Bystander BM stromal elements play a significant role in the disease setting.
Conclusions:
- The bone marrow stroma is integral to the pathogenesis of hematological neoplasms.
- Modifications in the BM stroma have a substantial impact on disease outcomes.
- Targeting the BM stroma presents a viable therapeutic avenue for hematological malignancies.
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