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Updated: Jun 3, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Invasive squamous cell carcinoma arising from chromoblastomycosis
Adawiyah Jamil1, Yin Yin Lee, Suganthi Thevarajah
1Department of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia. adda_jamil@yahoo.com
Medical Mycology
|April 1, 2011
Summary
Chromoblastomycosis, a tropical fungal infection, rarely leads to cancer. This case highlights invasive squamous cell carcinoma developing after 21 years of untreated chromoblastomycosis in an elderly male.
Area of Science:
- Mycology
- Dermatology
- Oncology
Background:
- Chromoblastomycosis is a chronic fungal infection affecting subcutaneous tissues, primarily in tropical climates.
- Malignant transformation of chromoblastomycosis is a rare but serious complication.
Observation:
- A 69-year-old male presented with a 21-year history of chromoblastomycosis.
- The chronic infection progressed to invasive squamous cell carcinoma, necessitating limb amputation.
Findings:
- Malignancy associated with chromoblastomycosis typically arises after 20-30 years of infection.
- Affected individuals are usually males over 60 with a history of inadequate treatment and relapses.
- Extremities are the most common sites for these carcinomas, correlating with chronic lesion locations.
Implications:
- This case underscores the importance of long-term monitoring for chromoblastomycosis patients.
- Early and adequate treatment may be crucial in preventing malignant transformation.
- Further research into the mechanisms of carcinogenesis in chronic mycoses is warranted.
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