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Updated: Jun 3, 2026

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On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
Published on: March 11, 2022
Simultaneous DSC-FTIR microspectroscopy used to screen and detect the co-crystal formation in real time
Tieh-Kang Wu1, Shan-Yang Lin, Hong-Liang Lin
1Department of Biotechnology, Yuanpei University, Hsin-Chu, Taiwan.
Bioorganic & Medicinal Chemistry Letters
|April 1, 2011
Abstract:
We first report that the formation of pharmaceutical co-crystal can be synchronously screened and confirmed by a simultaneous DSC-FTIR microspectroscopic system, in which this combined unique system giving spectroscopic and thermodynamic information could provide a easy and direct way for one step screening and qualitative detection of the co-crystal formation in real time.

