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Related Experiment Video

Updated: Jun 3, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Mortality in spondylarthritis.

Clément Prati¹, Pascal Claudepierre, Thao Pham

¹Service de rhumatologie, université de Franche-Comté, CHU, 1, boulevard Fleming, 25030 Besançon, France.

Joint Bone Spine

|April 1, 2011

Summary

Recent studies show that ankylosing spondylitis (AS) patients treated without radiation therapy do not have excess mortality. Cardiovascular disease remains the leading cause of death, but cancer risk is not increased.

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Area of Science:

Rheumatology
Epidemiology
Clinical Medicine

Background:

Ankylosing spondylitis (AS) is a chronic inflammatory condition impacting joints.
Previous reports suggested excess mortality in AS patients.
Improved treatment methods have emerged.

Purpose of the Study:

To review recent studies on mortality rates in ankylosing spondylitis patients.
To assess mortality without radiation therapy.
To identify causes of death in AS.

Main Methods:

Review of recent studies on AS patients treated with improved methods.
Analysis of mortality data excluding radiation therapy.
Examination of causes of death including cardiovascular, spinal, renal, and gastrointestinal diseases, as well as external causes.

Main Results:

Current evidence does not support excess mortality in AS patients treated without radiation therapy.
Cardiovascular disease is the primary cause of death, with a potentially slightly increased rate in AS.
Excess mortality is also noted for spinal disease, renal and gastrointestinal issues, alcohol abuse, injury, and suicide.
No increased risk of lymphoma or other malignancies was observed.

Conclusions:

Modern treatment approaches for ankylosing spondylitis appear to mitigate excess mortality.
Cardiovascular health and lifestyle factors like alcohol consumption require attention in AS patient management.
Further data from biologics registries will enhance understanding of long-term outcomes.