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Prognostic value of the Rose questionnaire: a validation with future coronary events in the SMART study

S Achterberg1, S S Soedamah-Muthu, M J M Cramer

  • 1Department of Neurology, Rudolf Magnus Institute of Neuroscience UMC Utrecht, Utrecht, The Netherlands. s.achterberg-2@umcutrecht.nl

European Journal of Preventive Cardiology
|April 1, 2011
PubMed

Insights

The Rose questionnaire, used for diagnosing angina pectoris, can effectively predict future coronary events. A shorter version with key questions performs as well as the full questionnaire for risk assessment.

Area of Science:

  • Cardiology
  • Epidemiology
  • Preventive Medicine

Background:

  • The Rose questionnaire is a standard tool for diagnosing angina pectoris in epidemiological research.
  • Its prognostic value for predicting future coronary events requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic capability of the Rose questionnaire for future coronary events.
  • To compare the predictive performance of different subsets of the Rose questionnaire against the full version.

Main Methods:

  • A cohort of 7916 patients with vascular disease or risk factors from the Second Manifestations of ARTerial disease (SMART) study were analyzed.
  • Four definitions of angina pectoris based on the Rose questionnaire were assessed.
  • Multivariable Cox regression models were used to analyze new coronary events and interventions over an average follow-up of 4.6 years.

Main Results:

  • The discriminatory ability of the four Rose questionnaire definitions for coronary events was similar, with areas under the receiver-operator characteristics curves ranging from 0.708 to 0.726.
  • The ability to improve risk stratification was comparable across the different definitions, indicating small differences between them.
  • No significant difference in predictive performance was observed between the full Rose questionnaire and a subset of its questions.

Conclusions:

  • A subset of questions from the Rose questionnaire demonstrates equivalent prognostic value for predicting coronary events compared to the full questionnaire.
  • These findings suggest that a simplified Rose questionnaire can be effectively used for cardiovascular risk assessment.
Abstract

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