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Prehypertension and cardiovascular risk factors in adults enrolled in a primary care programme
Aline B Nery1, Evandro T Mesquita, Jocemir R Lugon
1Department of Epidemiology and Biostatistics, Universidade Federal Fluminense (UFF), Niteroi, Rio de Janeiro, Brazil.
Insights
Prehypertension in Brazil is linked to cardiovascular risk factors like high BMI, triglycerides, and uric acid. Early identification in primary care can help prevent cardiovascular disease.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Prehypertension is associated with increased cardiovascular disease risk, often co-occurring with other risk factors.
- Limited data exists on prehypertension prevalence and its associated risk factors in Brazil.
- Understanding these associations is crucial for public health initiatives in Brazil.
Purpose of the Study:
- To determine the association between prehypertension and cardiovascular risk factors within a Brazilian public primary healthcare program.
- To identify key metabolic and demographic factors linked to prehypertension in this population.
Main Methods:
- A cross-sectional study design was employed.
- Generalized estimating equations were used to estimate associations.
- Results were reported as odds ratios (OR) with 95% confidence intervals (CI).
Main Results:
- Of 357 participants, 35.6% had prehypertension.
- Univariate analysis showed associations with male gender, age, salt intake, diabetes, BMI, uric acid, and lipids (excluding HDL).
- Adjusted analysis revealed significant associations for BMI (OR(a)=1.097), triglycerides (OR(a)=1.008), and uric acid (OR(a)=1.269).
- Triglyceride association remained significant after adjusting for BMI, indicating independence from obesity.
Conclusions:
- Prehypertension in Brazil is significantly associated with established cardiovascular risk factors.
- These findings highlight the importance of monitoring prehypertension in primary care settings.
- Identifying prehypertension serves as an early warning for potential cardiovascular disease, prompting timely intervention.
Background:
An increase in cardiovascular (CV) disease has been observed in prehypertensive subjects who frequently carry other cardiovascular risk factors. In Brazil, little is known about prehypertension and its association with cardiovascular risk factors.
Objective:
To estimate the association between prehypertension and cardiovascular risk factors in a public primary healthcare programme.
Methods:
Associations in this cross-sectional study were estimated on the basis of generalized estimating equations. Results are expressed as odds ratio (OR) or adjusted odds ratio (OR(a)) with 95% confidence interval (CI).
Results:
The 357 participants were classified as normotensive (64.4%) or prehypertensive (35.6%). In a univariate analysis, prehypertension was statistically associated with male gender, age, table salt use, diabetes, body mass index (BMI), uric acid, and all lipids except high-density lipoprotein cholesterol. When analysis was performed adjusting for gender, age, and table salt use, the association of each metabolic parameter with prehypertension, remained significant for BMI (OR(a) = 1.097; 95% CI 1.035-1.162), triglycerides (OR(a) = 1.008; 95% CI 1.003-1.013), and uric acid (OR(a) = 1.269; 95% CI 1.023- .576). To check for their independence of obesity, associations of triglycerides and uric acid with prehypertension were reanalysed after adjustment for BMI. The association of triglycerides remained statistically significant. A trend of association was present for uric acid. The prevalence of prehypertension paralleled the increase of the number of risk factors.
Conclusion:
Prehypertension in Brazil is associated with well-recognized cardiovascular risk factors even in a continuously monitored population such the one under study. Prehypertension can be a valuable clue to alert health professionals to treat underlying perturbations to prevent overt cardiovascular disease.
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