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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

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Strain-tailored double-disk synergy test detects extended-spectrum oxacillinases in Pseudomonas aeruginosa

Didier Hocquet1, Barbara Dehecq, Xavier Bertrand

  • 1Service de Bactériologie, Centre National de Référence de la Résistance aux Antibiotiques, Laboratoire Associé Pseudomonas aeruginosa, Centre Hospitalier Universitaire, Besançon, France. dhocquet@univ-fcomte.fr

Journal of Clinical Microbiology
|April 1, 2011
PubMed

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...