Related Experiment Video
Updated: Jun 3, 2026
09:42
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Does dementia increase risk of thrombolysis?: a case-control study
A Alshekhlee1, C-C Li, S-Y Chuang
1Souers Stroke Institute, Department of Neurology and Psychiatry, St. Louis University, 1438 S. Grand Blvd., St. Louis, MO 63104, USA. aalshekh@slu.edu
Neurology
|April 1, 2011
Summary
Thrombolysis for acute ischemic stroke in dementia patients did not increase risks of intracerebral hemorrhage or death compared to those without dementia. Intracerebral hemorrhage remained a predictor of mortality in both groups.
Area of Science:
- Neurology
- Geriatrics
- Internal Medicine
Background:
- Dementia poses challenges for thrombolysis in acute ischemic stroke (AIS).
- Assessing the impact of dementia on outcomes after thrombolysis is crucial.
Purpose of the Study:
- To evaluate the effect of dementia on intracerebral hemorrhage (ICH) and hospital mortality rates in AIS patients treated with thrombolysis.
- To compare outcomes of thrombolysis in AIS patients with and without dementia.
Main Methods:
- Utilized the National Inpatient Sample database (2000-2007) for patients with AIS.
- Identified dementia using ICD-9-CM codes and selected matched controls without dementia treated with thrombolysis.
Main Results:
- Among 35,557 dementia patients, 207 received thrombolysis.
- Thrombolysis in dementia patients showed similar ICH (5.80% vs 4.51%) and mortality (17.39% vs 14.49%) rates compared to matched non-dementia controls.
- Intracerebral hemorrhage was a significant predictor of mortality in both groups.
Conclusions:
- Thrombolysis for AIS in patients with dementia is not associated with increased ICH or mortality risk compared to non-dementia patients.
- Intracerebral hemorrhage remains a key predictor of mortality following thrombolysis, irrespective of dementia status.
Related Concept Videos
01:22Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
01:30Dementia
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
The progression of dementia is generally gradual.
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...