Related Experiment Video
Updated: Jun 3, 2026

Accurate Follicle Enumeration in Adult Mouse Ovaries
Published on: October 16, 2020
Predicting age at menopause from serum antimüllerian hormone concentration
Fahimeh Ramezani Tehrani1, Nezhat Shakeri, Masoud Solaymani-Dodaran
1Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ramezani@endocrine.ac.ir
Objective:
We aimed to estimate age at menopause using serum antimüllerian hormone (AMH) concentration.
Methods:
We randomly selected 266 study participants from a pool of 1,265 eligible women in the Tehran Lipid and Glucose Study cohort. We measured AMH levels three times at about 3-year intervals. There were 63 occurrences of menopause in our participants over an average of 6-year follow-up. We built an accelerated failure time model using serum AMH level at the start of follow-up to estimate age at menopause. The goodness of fit for the model was tested using Cox-Snell residuals and the Bland-Altman plot.
Results:
We estimated ages at menopause for different levels of serum AMH concentration among women aged 20 to 49 years. For those who reached menopause, serum AMH concentrations about 6 years before the event provided fairly accurate estimates of the age at menopause. The Bland-Altman plot showed an acceptable agreement between predicted and observed values.
Conclusions:
Serum AMH concentrations can reasonably forecast the age at menopause for individual women.
Related Concept Videos
Menopause
Oogenesis
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.