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Predicting age at menopause from serum antimüllerian hormone concentration
Fahimeh Ramezani Tehrani1, Nezhat Shakeri, Masoud Solaymani-Dodaran
1Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ramezani@endocrine.ac.ir
Menopause (New York, N.Y.)
|April 1, 2011
Summary
Serum antimüllerian hormone (AMH) levels can predict the menopausal transition. This study shows AMH concentration accurately estimates age at menopause in women aged 20-49.
Area of Science:
- Reproductive Endocrinology
- Biomarker Discovery
- Gerontology
Background:
- Menopause marks the end of reproductive capability.
- Predicting the menopausal transition is crucial for women's health management.
- Serum antimüllerian hormone (AMH) is a key indicator of ovarian reserve.
Purpose of the Study:
- To estimate the age at menopause using serum AMH concentration.
- To validate AMH as a predictive biomarker for menopausal onset.
Main Methods:
- Accelerated failure time modeling was employed.
- Serum AMH levels were measured at approximately 3-year intervals in 266 women.
- Model accuracy was assessed using Cox-Snell residuals and Bland-Altman plots.
Main Results:
- Serum AMH concentrations approximately 6 years prior to menopause provided accurate age estimations.
- The model demonstrated acceptable agreement between predicted and observed menopausal ages.
- Estimates were generated for women aged 20 to 49 years.
Conclusions:
- Serum AMH concentration is a reliable predictor of individual age at menopause.
- AMH offers a valuable tool for forecasting the menopausal transition.
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