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Updated: Jun 3, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
Published on: February 21, 2015
Copy number variations in affective disorders and meta-analysis.
Line Olsen1, Thomas Hansen, Srdjan Djurovic
1Institute for Biological Psychiatry, Mental Health Centre Sct. Hans, Roskilde, Norway.
Ten copy number variants (CNVs) previously linked to affective disorders were investigated in a large Nordic population. This study found no combined association between these specific CNVs and affective disorders.
Area of Science:
- Genetics
- Psychiatry
- Genomic research
Background:
- Previous studies identified 10 copy number variants (CNVs) potentially associated with affective disorders.
- These variants were found in an Amish family study and the Wellcome Trust Case-Control Consortium study.
Purpose of the Study:
- To investigate the association between 10 specific CNVs and affective disorders.
- To validate previous findings in a larger, independent cohort.
Main Methods:
- Combined analysis of three case-control samples from Denmark, Norway, and Iceland.
- Analysis included 1897 cases (1223 unipolar, 463 bipolar) and 11,231 controls.
- Genomic loci for 10 CNVs were examined.
Main Results:
- No statistically significant combined association was found between the 10 CNVs and affective disorders.
- The results did not replicate the overrepresentation observed in earlier studies.
Conclusions:
- The 10 CNVs investigated do not appear to be broadly associated with affective disorders in the studied Nordic populations.
- Further research is needed to understand the genetic underpinnings of affective disorders.
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