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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Mutation screening of PDZD2, GOLPH3, and MTMR12 genes in patients with schizophrenia

Benjamin P Ritter, Gary W Angelo, Martina Durner

    Psychiatric Genetics
    |April 1, 2011
    PubMed
    Abstract

    No abstract available in PubMed .

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    Genetic Screens02:46

    Genetic Screens

    Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
    Forward genetic screens
    Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
    Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

    Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

    Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
    Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

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