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Related Concept Videos

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Genomic DNA in Eukaryotes

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

Genomic DNA in Prokaryotes

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...

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Related Experiment Video

Updated: Jun 3, 2026

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

Single-cell genomics.

Tomer Kalisky¹, Stephen R Quake

¹Department of Bioengineering, Stanford University, Stanford, California, USA.

|April 1, 2011

Summary

This summary is machine-generated.

Single-cell genomic analysis offers novel insights into complex biological systems. These advanced techniques aid in dissecting tissue composition, discovering microbes, and performing genome-wide haplotyping.

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Detection of Copy Number Alterations Using Single Cell Sequencing

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Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

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Last Updated: Jun 3, 2026

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

Detection of Copy Number Alterations Using Single Cell Sequencing

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

Area of Science:

Genomics
Molecular Biology
Biotechnology

Background:

Understanding complex biological systems requires detailed cellular analysis.
Traditional methods often lack the resolution to study individual cells effectively.

Purpose of the Study:

To highlight the capabilities of single-cell genomic analysis.
To showcase applications in tissue composition, microbial discovery, and haplotyping.

Main Methods:

Utilizing single-cell techniques such as flow cytometry, microfluidics, PCR, and sequencing.
Applying these methods for genomic analysis at the single-cell level.

Main Results:

Enabling a deeper understanding of complex biological phenomena.
Facilitating the characterization of cellular composition in tissues.
Aiding in the identification of novel microbial species.
Supporting genome-wide haplotyping.

Conclusions:

Single-cell genomic analysis is a powerful approach for biological discovery.
These techniques provide unprecedented resolution for studying cellular and genomic information.