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Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Related Experiment Video

Updated: Jun 3, 2026

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

Published on: December 10, 2021

Neck contracture release with matriderm collagen/elastin dermal matrix.

John E Greenwood, Ian P Mackie

|April 1, 2011

Summary

This study shows immediate split-skin grafting over Matriderm dermal matrix is successful for difficult neck contracture release. While some contraction occurred, the patient was very satisfied with the functional and aesthetic outcome.

Area of Science:

Reconstructive surgery
Dermatology
Burn treatment

Background:

Neck contractures, often resulting from burns, significantly impair function and aesthetics.
Traditional treatments for severe contractures can be challenging, with limited reconstructive options.
Dermal matrices offer a potential solution for complex wound healing and reconstruction.

Purpose of the Study:

To evaluate the efficacy of immediate split-skin grafting over Matriderm dermal matrix in severe neck contracture release.
To assess graft take, functional outcome, and patient satisfaction following the procedure.
To determine the learning curve associated with this reconstructive technique.

Main Methods:

Performed aggressive neck contracture release with complete platysmectomy.

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Published on: July 4, 2019

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A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

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Published on: December 10, 2021

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

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Applied Matriderm dermal matrix followed by split-skin grafting.

Utilized Mepitel and vacuum-assisted closure (VAC) dressing for wound management.

Main Results:

Achieved near-complete graft take by day 7 post-surgery, with full take by day 9.
Observed some graft contraction and reduction in the degree of release at 4-month follow-up.
Reported high patient satisfaction despite observed contraction.

Conclusions:

Immediate split-skin grafting over Matriderm provides a viable solution for difficult neck contracture release.
The surgical technique demonstrates a manageable learning curve for complex postburn cases.
Postoperative contraction remains a challenge, consistent with other reconstructive methods.