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Endosome-escapable magnetic poly(amino acid) nanoparticles for cancer diagnosis and therapy
Hee-Man Yang1, Hyun Jin Lee, Chan Woo Park
1Department of Chemical and Biomolecular Engineering (BK21 Graduate Program), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
Chemical Communications (Cambridge, England)
|April 1, 2011
Abstract:
Endosome-escapable poly(amino acid) nanoparticles composed of iron oxide nanocrystals and anticancer drugs were prepared and demonstrated high T(2) relaxivity coefficients and higher efficacy attributed to the endosomolytic ability of the conjugated histidine moiety.
