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Related Concept Videos

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

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Related Experiment Video

Updated: Jun 3, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

An oscillating molecular turnstile.

Thomas Lang1, Ernest Graf, Nathalie Kyritsakas

  • 1UMR UDS-CNRS 7140, Universite de Strasbourg, Institut Le Bel, 4 rue Blaise Pascal, CS90032 67081 Strasbourg, France.

Dalton Transactions (Cambridge, England : 2003)
|April 1, 2011
PubMed
Summary
This summary is machine-generated.

A novel molecular turnstile oscillates between two states when a silver cation is added. This molecular machine

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Last Updated: Jun 3, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

Experimental Methods for Trapping Ions Using Microfabricated Surface Ion Traps
11:45

Experimental Methods for Trapping Ions Using Microfabricated Surface Ion Traps

Published on: August 17, 2017

Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

Area of Science:

  • Supramolecular Chemistry
  • Molecular Machines
  • Porphyrin Chemistry

Background:

  • Molecular machines offer precise control over molecular motion.
  • Porphyrin-based systems are versatile platforms for constructing complex molecular architectures.

Purpose of the Study:

  • To design and synthesize an oscillating molecular turnstile.
  • To investigate the stimulus-responsive behavior of the designed molecular system.

Main Methods:

  • Synthesis of a porphyrin-based stator and a pyridyl-containing rotor.
  • Investigation of molecular motion in solution using spectroscopic techniques.
  • Control of the turnstile's state using silver cations and temperature changes.

Main Results:

  • The molecular turnstile exhibits free rotation in solution.
  • Addition of silver cations induces oscillatory movement between two states.
  • The open-closed states can be reversibly switched using temperature and chemical stimuli (Et(4)NBr).

Conclusions:

  • A functional oscillating molecular turnstile has been developed.
  • The system demonstrates controllable switching between open and closed states.
  • This work contributes to the advancement of switchable molecular devices.