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Related Experiment Video

Updated: Jun 3, 2026

Quantifying Mixing using Magnetic Resonance Imaging

Quantifying Mixing using Magnetic Resonance Imaging

Published on: January 25, 2012

Meloxicam carbopol-based gels: characterization and evaluation.

Rashmi Sareen¹, Sandeep Kumar, G D Gupta

¹Abhilashi College of Pharmacy, Tanda, Ner Chowk, Mandi (HP), India. sareenrashmi@gmail.com

Current Drug Delivery

|April 2, 2011

Summary

This study developed meloxicam hydrogels for topical use, finding sesame oil enhanced drug release. Optimized formulations show potential for effective topical pain management.

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Last Updated: Jun 3, 2026

Quantifying Mixing using Magnetic Resonance Imaging

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Published on: January 25, 2012

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Topical drug delivery systems are crucial for localized treatment.
Hydrogels offer advantages like high water content and flexibility for drug formulation.
Meloxicam is a non-steroidal anti-inflammatory drug used for pain and inflammation.

Purpose of the Study:

To formulate and evaluate meloxicam-loaded hydrogels for topical application.
To investigate the impact of penetration enhancers on meloxicam release.
To compare the efficacy of different penetration enhancers in hydrogel formulations.

Main Methods:

Hydrogels were prepared using carbopol-940 and carbopol-934 as polymers.
Various penetration enhancers (tween 80, oleic acid, sesame oil) were incorporated at 1% and 2% concentrations.
Formulations were evaluated for physical properties, drug content, in vitro drug permeation through pig skin, and stability.

Main Results:

All formulations exhibited good homogeneity and drug content above 93%.
Formulation F(14) with carbopol-934 and 2% sesame oil showed 99% drug release, following zero-order kinetics.
Increased penetration enhancer concentration correlated with higher drug release rates.

Conclusions:

Sesame oil at 2% concentration significantly enhanced meloxicam release from carbopol-934 hydrogels.
The developed hydrogels demonstrate potential for effective topical delivery of meloxicam.
Further studies are warranted to explore in vivo efficacy and safety.