Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An intelligent gradient-guided hybrid inpainting framework for brain MRI reconstruction and Alzheimer's disease classification in connected healthcare systems.

Frontiers in medicine·2026
Same author

MagmaFlow: A desktop platform for artificial intelligence-driven expression analysis.

FEBS open bio·2026
Same author

The Impact of Modification of the Coumarin Moiety on Cancer Treatment.

Mini reviews in medicinal chemistry·2026
Same author

Comment on "Pain in individuals with adolescent idiopathic scoliosis: prevalence and association with physical function and psychosocial well-being using patient-reported outcome measures".

Spine deformity·2026
Same author

Ultrasound-guided midline versus paramedian approach for combined spinal-epidural anesthesia: A randomized controlled study.

Journal of anaesthesiology, clinical pharmacology·2026
Same author

Assessment of changes in lung aeration and diaphragmatic function using ultrasonography in laparoscopic abdominal surgery: a prospective observational study.

Anesthesia and pain medicine·2026
Same journal

Mechanistic and Phytochemical Basis of Shexiang Xintongning Against Atherosclerosis: Insights from Network Pharmacology and Molecular Docking.

Current drug delivery·2026
Same journal

Design and Optimization of Beta-Caryophyllene Nanoemulgel for Enhanced Antihyperlipidemic Activity: A Response Surface Approach.

Current drug delivery·2026
Same journal

Optimization of Andrographolide Nanocrystal-loaded Liposomes by Box-Behnken Design and its <i>In vitro</i> and <i>In vivo</i> Evaluation.

Current drug delivery·2026
Same journal

Development and Assessment of Rutin/Betamethasone-Loaded PAN-PVP Nanofibers for Wound Healing Applications.

Current drug delivery·2026
Same journal

QbD-Driven Rational Design of Vancomycin-Loaded Nanocubosome <i>In situ</i> Ocular Gels: Augmenting Precorneal Retention and Improving Anti-MRSA Keratitis Treatment.

Current drug delivery·2026
Same journal

Curcumin-based Nanotherapeutics to Combat Neurodegenerative Disease: Drug Delivery Strategies and Therapeutic Potential.

Current drug delivery·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film
04:09

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film

Published on: December 13, 2024

Fast dissolving films: a review.

Ankita Chaturvedi1, Pranati Srivastava, Sunita Yadav

  • 1Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut - 250005, UP, India. smartankita23@gmail.com

Current Drug Delivery
|April 2, 2011
PubMed
Summary
This summary is machine-generated.

Fast dissolving films offer a superior oral drug delivery method for chronic conditions, improving patient compliance by masking bitter tastes. These thin films dissolve rapidly on the tongue, providing faster therapeutic blood levels than traditional dosage forms.

More Related Videos

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Fabrication of Large-area Free-standing Ultrathin Polymer Films
10:08

Fabrication of Large-area Free-standing Ultrathin Polymer Films

Published on: June 3, 2015

Related Experiment Videos

Last Updated: Jun 3, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film
04:09

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film

Published on: December 13, 2024

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Fabrication of Large-area Free-standing Ultrathin Polymer Films
10:08

Fabrication of Large-area Free-standing Ultrathin Polymer Films

Published on: June 3, 2015

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Conventional oral drug delivery faces challenges like poor patient compliance, especially for chronic conditions.
  • Fast dissolving films (FDFs) have emerged as an innovative alternative to traditional tablets and capsules.
  • FDFs offer advantages such as rapid dissolution, improved taste masking, and enhanced patient acceptance.

Purpose of the Study:

  • To review recent patents and manufacturing techniques for fast dissolving films.
  • To evaluate the parameters used in assessing the quality of fast dissolving films.
  • To highlight the benefits of FDFs for oral drug delivery in chronic disease management.

Main Methods:

  • Literature review focusing on patents related to fast dissolving films.
  • Analysis of various manufacturing techniques for FDFs.
  • Examination of key parameters for evaluating FDF performance.

Main Results:

  • Fast dissolving films dissolve in under a minute on the tongue.
  • These films are effective for taste masking and improving patient compliance.
  • FDFs demonstrate potential for faster therapeutic blood levels in chronic conditions.

Conclusions:

  • Fast dissolving films represent a significant advancement in oral drug delivery.
  • They offer a patient-centric approach, particularly beneficial for managing chronic disorders.
  • Further research and development in FDF technology are warranted to optimize drug delivery outcomes.