Related Experiment Video
Updated: Jun 3, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
[Clinical, radiological and arthroscopic graduation of knee osteoarthritis]
Anne Birgitte Simonsen1, Anette Jørgensen, Mogens Berg Laursen
1Ortopædkirurgien Region Nordjylland, Århus Universitetshospital, Aalborg Sygehus, 9000 Aalborg, Denmark.
Abstract:
According to the American College of Rheumatology criteria, knee osteoarthritis can be diagnosed solely from clinical or radiological findings. The cardinal symptom is pain during activity or at rest. To score pain and functional deficits, several systems have been developed among which visual analogue scale for pain scoring and Western Ontario and McMaster Universities osteoarthritis index, Knee Injury and Osteoarthritis Outcome Scale or Oxford Knee Score for combined scoring of pain and function are the ones used most frequently. The severity of cartilage degradation is determined by X-ray and arthroscopy. There is still not consensus on magnetic resonance imaging criteria for the diagnosis and severity of knee osteoarthritis.
