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Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Role of Matrix Metalloproteases in Degradation of ECM01:23

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
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The Bone Matrix01:18

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
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Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach
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Published on: August 26, 2013

Bone morphogenetic protein (BMP)1-3 enhances bone repair.

Lovorka Grgurevic1, Boris Macek, Mladen Mercep

  • 1Laboratory for Mineralized Tissues, Center for Translational and Clinical Research and Orthopaedic Surgery, University of Zagreb, 10000 Zagreb, Croatia.

Biochemical and Biophysical Research Communications
|April 2, 2011
PubMed
Summary

Bone morphogenetic protein 1 isoform 3 (BMP1-3) circulates in plasma and aids bone repair. This study shows BMP1-3 enhances bone healing and may serve as a novel bone biomarker.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Orthopedics

Background:

  • Bone morphogenetic protein 1 (BMP-1) is an astacin metalloproteinase involved in extracellular matrix (ECM) and growth factor processing.
  • The BMP1-3 isoform of BMP-1 has been identified in human plasma and elevated levels observed in acute bone fracture patients.

Purpose of the Study:

  • To investigate the role of circulating BMP1-3 in bone repair.
  • To evaluate BMP1-3 as a potential biomarker for bone healing.

Main Methods:

  • Systemic and local administration of recombinant human BMP1-3 in rat and rabbit fracture models.
  • Neutralization of endogenous BMP1-3 using polyclonal antibodies.
  • In vitro studies using MC3T3-E(1) osteoblast-like cells and bone marrow mesenchymal stem cells.

Main Results:

  • Recombinant BMP1-3 significantly enhanced bone healing in vivo.
  • Antibody-mediated neutralization of BMP1-3 delayed bone union.
  • In vitro, BMP1-3 increased collagen type I and osteocalcin expression and promoted mineralized bone nodule formation.

Conclusions:

  • BMP1-3 is a novel systemic regulator of bone repair.
  • Circulating BMP1-3 shows potential as a diagnostic biomarker for bone healing.