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Visceral leishmaniasis: elimination with existing interventions.
Greg Matlashewski1, Byron Arana, Axel Kroeger
1Special Programme for Research and Training in Tropical Diseases, WHO, Geneva, Switzerland.
The Lancet. Infectious Diseases
|April 2, 2011
Summary
Effective use of current interventions can significantly reduce infectious disease burdens. Visceral leishmaniasis elimination in the Indian subcontinent is achievable through community-level case detection and treatment with liposomal amphotericin B.
Area of Science:
- Tropical medicine
- Infectious disease control
- Public health
Background:
- Infectious diseases pose a significant global health burden.
- Advances in diagnostics and therapeutics offer new control strategies.
- Visceral leishmaniasis elimination is a potential public health goal.
Purpose of the Study:
- To outline a strategy for visceral leishmaniasis elimination in the Indian subcontinent.
- To emphasize the importance of community-level intervention implementation.
Main Methods:
- Active case finding in endemic villages.
- Treatment with single-dose liposomal amphotericin B at primary healthcare centers.
- Introduction of combination therapies (miltefosine and paromomycin) post-elimination.
Main Results:
- The study proposes a feasible pathway towards visceral leishmaniasis elimination.
- Effective implementation of existing interventions is key to achieving targets.
- Combination therapies are crucial for long-term drug availability and resistance management.
Conclusions:
- Visceral leishmaniasis elimination is attainable in the Indian subcontinent.
- Community-based strategies focusing on early detection and treatment are essential.
- Sustained efforts and strategic drug use are vital for long-term disease control.
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