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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Related Experiment Video

Updated: Jun 3, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

[Methicillin-resistant Staphylococcus aureus disease in Panama].

K Luciani1, J Nieto-Guevara, X Sáez-Llorens

  • 1Servicio de Infectología, Hospital del Niño, Panamá, República de Panamá. kathialuciani@yahoo.com

Anales De Pediatria (Barcelona, Spain : 2003)
|April 2, 2011
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) infections in children under 15 are uncommon in Panama, with a low incidence of 8.9%. Active surveillance is recommended to prevent hospital-acquired infections and guide treatment based on local data.

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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

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Last Updated: Jun 3, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Pediatrics

Context:

  • Methicillin-resistant Staphylococcus aureus (MRSA) infections are a growing global health concern.
  • MRSA infections present a wide clinical spectrum, from nasal colonization to severe invasive diseases.
  • Understanding MRSA epidemiology in pediatric populations is crucial for effective public health strategies.

Purpose:

  • To determine the frequency, clinical features, and risk factors of MRSA infections in children under 15 years old.
  • To establish the prevalence of MRSA colonization and its antimicrobial susceptibility patterns.
  • To provide data for local treatment guidelines and infection control measures.

Summary:

  • A retrospective study in Panama found an 8.9% MRSA infection rate among 146 children with Staphylococcus aureus infections.
  • Community-acquired MRSA constituted 38.5% of isolates, with no identified risk factors for MRSA infection.
  • Nasal carriage prevalence was 8.3%, and resistance to erythromycin and clindamycin was 15.4%.

Impact:

  • The study indicates a low incidence of MRSA infections in this pediatric cohort compared to other regions.
  • Findings underscore the need for ongoing surveillance to prevent nosocomial MRSA infections.
  • Results support the development of evidence-based treatment guidelines tailored to local epidemiological data.