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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
Antidiarrhoeal and antiulcer activities of Hippocratea africana root extract
Jude Efiom Okokon1, Henry Dan Akpan, Emem Ekpo Umoh
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, and Department of Chemical Pathology, University of Uyo Teaching Hospital, Uyo, Nigeria. judeefiom@yahoo.com
Abstract:
The effect of ethanol root extract of H. africana on experimentally induced diarrhoea and ulcer was studied in rodents. The extract (200-600 mg/kg) considerably inhibited castor oil induced diarrhoea, small intestine transit time and castor oil induced fluid accumulation as well as indomethacin and ethanol induced ulcer models. The effect of the extract in these models was comparable to the various standard drugs used. The root extract of H. africana has antidiarrhoeal and antiulcer properties which justify its uses in ethnomedicine.
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