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Electrophilic fatty acids regulate matrix metalloproteinase activity and expression.

Gustavo Bonacci1, Francisco J Schopfer, Carlos I Batthyany

  • 1Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

The Journal of Biological Chemistry
|April 2, 2011
PubMed
Summary

Nitro-fatty acids (NO(2)-FA) activate matrix metalloproteinases (MMPs) by modifying their cysteine switch domain. These compounds also reduce MMP expression, suggesting a dual role in limiting inflammatory processes.

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