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Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension

Charlotte H Coles1, Yingjie Shen, Alan P Tenney

  • 1Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

Science (New York, N.Y.)
|April 2, 2011
PubMed
Summary

Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs) have opposite effects on sensory neuron extension via receptor protein tyrosine phosphatase sigma (RPTPσ). RPTPσ mediates inhibition by CSPGs and promotion by HSPGs, revealing a novel regulatory mechanism.

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