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Updated: Jun 3, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Recurrent high-dose intravenous methylprednisolone succinate pulse therapy-induced hepatopathy in a patient with
Daisuke Furutama1, Fumiharu Kimura, Keiichi Shinoda
1First Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan. in1110@poh.osaka-med.ac.jp
Objective:
We describe recurrent and reversible hepatopathy in a girl with multiple sclerosis (MS) after glucocorticoid pulse therapy, to point out the possibility that glucocorticoid may harm the liver.
Clinical Presentation And Intervention:
An 11-year-old girl with MS, who was treated with high-dose methylprednisolone succinate pulse therapy, developed elevation of liver enzymes. The episodes of hepatopathy occurred 1-5 weeks after the therapy and disappeared within several weeks. The examination for antinuclear antibody and viruses which can cause hepatitis produced negative results.
Conclusion:
The present case emphasizes the possible effects of high-dose glucocorticoids in the induction of liver enzymes and the importance of follow-up liver tests after pulse therapy.
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