Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
Propagation of Action Potentials01:23

Propagation of Action Potentials

The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Direct Motor Pathways01:11

Direct Motor Pathways

The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and the...
Indirect Motor Pathways01:22

Indirect Motor Pathways

The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dermo-cosmetic spray containing Rhealba oat plantlets and Uncaria tomentosa extract in patients with mild-to-moderate cutaneous pain.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Relations between the Raman spectra and molecular structure of selected carotenoids: DFT study of α-carotene, β-carotene, γ-carotene and lycopene.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2022
Same author

Influence of nanocrystal size on the in vivo absorption kinetics of caffeine after topical application.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2021
Same author

Corrigendum to "DFT study of Raman spectra of polyenes and ß-carotene: Dependence on length of polyene chain and isomer type" [Spectrochim. Acta A: Mol. Biomol. Spectrosc. 255 (2021) 119668].

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2021
Same author

Blind source separation of molecular components of the human skin in vivo: non-negative matrix factorization of Raman microspectroscopy data.

The Analyst·2021
Same author

DFT study of Raman spectra of polyenes and ß-carotene: Dependence on length of polyene chain and isomer type.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2021

Related Experiment Video

Updated: Jun 3, 2026

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
10:54

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Published on: May 22, 2021

Pathways of lateral spreading.

U Jacobi1, S Schanzer, H-J Weigmann

  • 1Department of Dermatology, Center of Experimental and Applied Cutaneous Physiology, Charité - Universitätsmedizin Berlin, Germany.

Skin Pharmacology and Physiology
|April 2, 2011
PubMed
Summary

Skin furrows act as pathways for lateral spreading of topical substances like UV filters. This study visualizes and quantifies how substances spread on the skin, revealing furrows as conduits and follicles as reservoirs.

More Related Videos

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy
05:50

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy

Published on: November 1, 2021

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array
09:48

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Published on: March 27, 2015

Related Experiment Videos

Last Updated: Jun 3, 2026

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
10:54

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Published on: May 22, 2021

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy
05:50

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy

Published on: November 1, 2021

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array
09:48

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Published on: March 27, 2015

Area of Science:

  • Dermatology
  • Cosmetic Science
  • Pharmaceutics

Background:

  • Topical application of substances involves parallel lateral spreading and skin penetration.
  • Understanding substance distribution is crucial for optimizing topical formulations.
  • Skin surface topography influences the spread of applied agents.

Purpose of the Study:

  • To quantitatively and visually investigate the pathways of lateral spreading for topical substances.
  • To determine the influence of skin surface structures on substance distribution.
  • To analyze the spread of a UV filter (butyl methoxydibenzoylmethane) in an o/w emulsion.

Main Methods:

  • Application of butyl methoxydibenzoylmethane in an o/w emulsion on forearm and back.
  • Tape stripping to quantify substance recovery inside and outside the application area.
  • Photography and laser scanning microscopy for visual analysis of lateral spreading.
  • Assessment of skin characteristics: transepidermal water loss, pH, hydration, and sebum rate.

Main Results:

  • Lateral spreading of the UV filter was observed on both forearm and back.
  • A preferred direction of lateral spreading, parallel to the body axis, was noted on the back.
  • Skin furrows were identified as preferential pathways for lateral spreading.
  • Skin follicles acted as reservoirs for the applied substance.

Conclusions:

  • Skin surface topography, specifically furrows, significantly directs the lateral spreading of topical substances.
  • Follicles play a role in retaining applied substances, influencing their distribution.
  • These findings are important for the design and efficacy of topical formulations, particularly UV filters.