Related Experiment Video
Updated: Jun 3, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
New insights into the pathogenesis of cellular crescents
Sunita K S Singh1, Marie Jeansson, Susan E Quaggin
1Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Purpose Of Review:
This review discusses the recent evidence that intrinsic glomerular cells including podocytes, parietal epithelial cells and progenitor cells within Bowman's capsule contribute to cellular crescents.
Recent Findings:
Using a variety of newer molecular markers and lineage tracing experiments, investigators have clearly demonstrated that glomerular cells play a key role in the development and progression of cellular crescents in experimental and human disease.
Summary:
Crescentic glomerulonephritis is associated with significant morbidity and mortality. Current therapies target the immune system. The recent finding that nonimmune cells also play a role in crescent formation highlights the need to identify alternate and complimentary therapeutic strategies.
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