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Updated: Jun 3, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
Published on: August 9, 2014
Anion exchanger 1 in red blood cells and kidney: Band 3's in a pod
Fiona Wu1, Timothy J Satchwell, Ashley M Toye
1School of Clinical Sciences, University of Bristol, Bristol, UK. fiona.wu@bris.ac.uk
Abstract:
The bicarbonate/chloride exchanger 1 (AE1, Band 3) is abundantly expressed in the red blood cell membrane, where it is involved in gas exchange and functions as a major site of cytoskeletal attachment to the erythrocyte membrane. A truncated kidney isoform (kAE1) is highly expressed in type A intercalated cells of the distal tubules, where it is vital for urinary acidification. Recently, kAE1 has emerged as a novel physiologically significant protein in the kidney glomerulus. This minireview will discuss the known interactions of kAE1 in the podocytes and the possible mechanisms whereby this important multispanning membrane protein may contribute to the function of the glomerular filtration barrier and prevent proteinuria.
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